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Research articles

Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms

Brolin, Emma; Ingelsson, Martin; Bergström, Joakim; Erlandsson, Anna

Part of Cellular and molecular neurobiology, p. 3023-3035, 2023.

DOI for Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms Download full text (pdf) of Altered Distribution of SNARE Proteins in Primary Neurons Exposed to Different Alpha-Synuclein Proteoforms

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Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy

Donadio, Vincenzo; Incensi, Alex; Rizzo, Giovanni; Westermark, Gunilla T. et al.

Part of Brain, p. 1065-1074, 2023.

DOI for Phosphorylated α-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy
Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

Faresjö, Rebecca; Sehlin, Dag; Syvänen, Stina

Part of Fluids and Barriers of the CNS, 2023.

DOI for Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody Download full text (pdf) of Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody

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Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Metzendorf, Nicole G.; Wik, Elin; Roshanbin, Sahar et al.

Part of Alzheimer's Research & Therapy, 2023.

DOI for Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease Download full text (pdf) of Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

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Long-term effects of amyloid-beta deposits in human iPSC-derived astrocytes

Konstantinidis, Evangelos; Dakhel, Abdulkhalek; Beretta, Chiara; Erlandsson, Anna

Part of Molecular and Cellular Neuroscience, 2023.

DOI for Long-term effects of amyloid-beta deposits in human iPSC-derived astrocytes Download full text (pdf) of Long-term effects of amyloid-beta deposits in human iPSC-derived astrocytes

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Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function

Konstantinidis, Evangelos; Portal, Benjamin; Mothes, Tobias J.; Beretta, Chiara et al.

Part of Journal of Neuroinflammation, 2023.

DOI for Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function Download full text (pdf) of Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function

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The G51D SNCA mutation generates a slowly progressive alpha-synuclein strain in early-onset Parkinson's disease

Lau, Heather H. C.; Martinez-Valbuena, Ivan; So, Raphaella W. L.; Mehra, Surabhi et al.

Part of Acta neuropathologica communications, 2023.

DOI for The G51D SNCA mutation generates a slowly progressive alpha-synuclein strain in early-onset Parkinson's disease Download full text (pdf) of The G51D SNCA mutation generates a slowly progressive alpha-synuclein strain in early-onset Parkinson's disease

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Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease

Luo, Jiao; Thomassen, Jesper Qvist; Bellenguez, Celine; Grenier-Boley, Benjamin et al.

Part of JAMA Network Open, 2023.

DOI for Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease Download full text (pdf) of Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease

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Size matters: the impact of nucleus size on results from spatial transcriptomics

Mohammadi, Elyas; Chojnowska, Katarzyna; Bienkowski, Michal; Kostecka, Anna et al.

Part of Journal of Translational Medicine, 2023.

DOI for Size matters: the impact of nucleus size on results from spatial transcriptomics Download full text (pdf) of Size matters: the impact of nucleus size on results from spatial transcriptomics

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Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology

Mothes, Tobias; Portal, Benjamin; Konstantinidis, Evangelos; Eltom, Khalid et al.

Part of Acta neuropathologica communications, 2023.

DOI for Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology Download full text (pdf) of Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology

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Genetic insights into resting heart rate and its role in cardiovascular disease

van de Vegte, Yordi; Eppinga, Ruben P.; van der Ende, M. Yldau; Hagemeijer, Yanick et al.

Part of Nature Communications, 2023.

DOI for Genetic insights into resting heart rate and its role in cardiovascular disease Download full text (pdf) of Genetic insights into resting heart rate and its role in cardiovascular disease

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Studies on alpha-synuclein and islet amyloid polypeptide interaction

Wang, Ye; Bergström, Joakim; Ingelsson, Martin; Westermark, Gunilla

Part of Frontiers in Molecular Biosciences, 2023.

DOI for Studies on alpha-synuclein and islet amyloid polypeptide interaction Download full text (pdf) of Studies on alpha-synuclein and islet amyloid polypeptide interaction

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Synaptic density in aging mice measured by [18F]SynVesT-1 PET

Xiong, Mengfei; Roshanbin, Sahar; Sehlin, Dag; Hansen, Hanne D. et al.

Part of NeuroImage, 2023.

DOI for Synaptic density in aging mice measured by [18F]SynVesT-1 PET Download full text (pdf) of Synaptic density in aging mice measured by [18F]SynVesT-1 PET

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Amyloid-beta accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism

Zyśk, Marlena; Beretta, Chiara; Naia, Luana; Dakhel, Abdulkhalek et al.

Part of Journal of Neuroinflammation, 2023.

DOI for Amyloid-beta accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism Download full text (pdf) of Amyloid-beta accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism

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Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice

Aniszewska, Agata; Bergström, Joakim; Ingelsson, Martin; Ekmark-Lewén, Sara

Part of Brain and Behavior, 2022.

DOI for Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice Download full text (pdf) of Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice

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New insights into the genetic etiology of Alzheimer's disease and related dementias

Bellenguez, Celine; Giedraitis, Vilmantas; Ingelsson, Martin; Lambert, Jean-Charles

Part of Nature Genetics, p. 412-436, 2022.

DOI for New insights into the genetic etiology of Alzheimer's disease and related dementias Download full text (pdf) of New insights into the genetic etiology of Alzheimer's disease and related dementias

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Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping

Belloy, Michael E.; Eger, Sarah J.; Le Guen, Yann; Damotte, Vincent et al.

Part of Alzheimer's Research & Therapy, 2022.

DOI for Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping Download full text (pdf) of Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping

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ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein

Bonvicini, Gillian; Syvänen, Stina; Andersson, Ken G. G.; Haaparanta-Solin, Merja et al.

Part of Translational Neurodegeneration, 2022.

DOI for ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein Download full text (pdf) of ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer's disease with a bispecific, brain-penetrating fusion protein

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A beta and tau prions feature in the neuropathogenesis of Down syndrome

Condello, Carlo; Maxwell, Alison M.; Castillo, Erika; Aoyagi, Atsushi et al.

Part of Proceedings of the National Academy of Sciences of the United States of America, 2022.

DOI for A beta and tau prions feature in the neuropathogenesis of Down syndrome
Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3

de la Rosa, Andres; Metzendorf, Nicole G.; Morrison, Jamie; Faresjö, Rebecca et al.

Part of Scientific Reports, 2022.

DOI for Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3 Download full text (pdf) of Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3

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Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies

Faresjö, Rebecca; Lindberg, Hanna; Stahl, Stefan; Lofblom, John et al.

Part of Pharmaceutical research, p. 1509-1521, 2022.

DOI for Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies Download full text (pdf) of Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies

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Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

Jansen, Ris E.; van der Lee, Sven J.; Gomez-Fonseca, Duber; de Rojas, Itziar et al.

Part of Acta Neuropathologica, p. 821-842, 2022.

DOI for Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers Download full text (pdf) of Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers

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Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's A beta amyloidosis

Jiang, Richeng; Smailovic, Una; Haytural, Hazal; Tijms, Betty M. et al.

Part of Acta neuropathologica communications, 2022.

DOI for Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's A beta amyloidosis Download full text (pdf) of Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's A beta amyloidosis

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Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

Julku, Ulrika; Xiong, Mengfei; Wik, Elin; Roshanbin, Sahar et al.

Part of Fluids and Barriers of the CNS, 2022.

DOI for Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis Download full text (pdf) of Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

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Advances in the development of new biomarkers for Alzheimer's disease

Klyucherev, Timofey O.; Olszewski, Pawel K.; Shalimova, Alena; Chubarev, Vladimir N. et al.

Part of Translational Neurodegeneration, 2022.

DOI for Advances in the development of new biomarkers for Alzheimer's disease Download full text (pdf) of Advances in the development of new biomarkers for Alzheimer's disease

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CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation

Konstantinidis, Evangelos; Molisak, Agnieszka; Perrin, Florian; Streubel-Gallasch, Linn et al.

Part of Molecular Therapy Nucleic Acids, p. 450-461, 2022.

DOI for CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation Download full text (pdf) of CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation

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Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease

Le Guen, Yann; Belloy, Michael E.; Grenier-Boley, Benjamin; de Rojas, Itziar et al.

Part of JAMA Neurology, p. 652-663, 2022.

DOI for Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease
Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation

Libard, Sylwia; Giedraitis, Vilmantas; Kilander, Lena; Ingelsson, Martin et al.

Part of Journal of Alzheimer's Disease, p. 1601-1614, 2022.

DOI for Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation Download full text (pdf) of Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation

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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Mahajan, Anubha; Spracklen, Cassandra N.; Zhang, Weihua; Ng, Maggie C. Y. et al.

Part of Nature Genetics, p. 560-572, 2022.

DOI for Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

Meier, Silvio R.; Sehlin, Dag; Roshanbin, Sahar; Lim Falk, Victoria et al.

Part of Journal of Nuclear Medicine, p. 302-309, 2022.

DOI for ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention Download full text (pdf) of ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

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Passive and receptor mediated brain delivery of an anti-GFAP nanobody

Meier, Silvio R.; Sehlin, Dag; Syvänen, Stina

Part of Nuclear Medicine and Biology, p. 128-134, 2022.

DOI for Passive and receptor mediated brain delivery of an anti-GFAP nanobody Download full text (pdf) of Passive and receptor mediated brain delivery of an anti-GFAP nanobody

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Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia

Pagnon de la Vega, María; Näslund, Carl; Brundin, RoseMarie; Lannfelt, Lars et al.

Part of BMC Genomics, 2022.

DOI for Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia Download full text (pdf) of Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia

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A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

Rofo, Fadi; Meier, Silvio R.; Metzendorf, Nicole G.; Morrison, Jamie et al.

Part of NEUROTHERAPEUTICS, p. 1588-1602, 2022.

DOI for A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice Download full text (pdf) of A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

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Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

Rofo, Fadi; Metzendorf, Nicole; Saubi, Cristina; Suominen, Laura et al.

Part of Alzheimer's Research & Therapy, 2022.

DOI for Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease Download full text (pdf) of Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

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Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

Roshanbin, Sahar; Julku, Ulrika; Xiong, Mengfei; Eriksson, Jonas et al.

Part of Pharmaceutics, 2022.

DOI for Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody Download full text (pdf) of Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

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In vivo imaging of alpha-synuclein with antibody-based PET

Roshanbin, Sahar; Xiong, Mengfei; Hultqvist, Greta; Soderberg, Linda et al.

Part of Neuropharmacology, 2022.

DOI for In vivo imaging of alpha-synuclein with antibody-based PET Download full text (pdf) of In vivo imaging of alpha-synuclein with antibody-based PET

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Targeted Gene Therapy to Treat Disorders of the Central Nervous System

Sasikumar, Sanskriti; Ingelsson, Martin

Part of Movement Disorders, p. 892-892, 2022.

DOI for Targeted Gene Therapy to Treat Disorders of the Central Nervous System
Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

Schlein, Eva; Syvänen, Stina; Rokka, Johanna; Gustavsson, Tobias et al.

Part of Molecular Pharmaceutics, p. 4111-4122, 2022.

DOI for Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging Download full text (pdf) of Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

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Professor Margareta Hammarlund-Udenaes: a Modern and Visionary Mentor

Syvänen, Stina; Fridén, Markus

Part of Pharmaceutical research, p. 1291-1296, 2022.

DOI for Professor Margareta Hammarlund-Udenaes: a Modern and Visionary Mentor
PET Imaging in Preclinical Anti-Aβ Drug Development

Syvänen, Stina; Meier, Silvio R.; Roshanbin, Sahar; Xiong, Mengfei et al.

Part of Pharmaceutical research, p. 1481-1496, 2022.

DOI for PET Imaging in Preclinical Anti-Aβ Drug Development Download full text (pdf) of PET Imaging in Preclinical Anti-Aβ Drug Development

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Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?

van den Broek, Sara Lopes; Shalgunov, Vladimir; Vazquez, Rocio Garcia; Beschorner, Natalie et al.

Part of Pharmaceuticals, 2022.

DOI for Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible? Download full text (pdf) of Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?

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VALZ-Pilot: High-dose valacyclovir treatment in patients with early-stage Alzheimer's disease

Weidung, Bodil; Hemmingsson, Eva-Stina; Olsson, Jan; Sundström, Torbjörn et al.

Part of Alzheimer’s & Dementia, 2022.

DOI for VALZ-Pilot: High-dose valacyclovir treatment in patients with early-stage Alzheimer's disease Download full text (pdf) of VALZ-Pilot: High-dose valacyclovir treatment in patients with early-stage Alzheimer's disease

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Differential DNA methylation of the genes for amyloid precursor protein, tau and neurofilaments in human traumatic brain injury

Abu Hamdeh, Sami; Ciuculete, Diana-Maria; Sarkisyan, Daniil; Bakalkin, Georgy et al.

Part of Journal of Neurotrauma, p. 1679-1688, 2021.

DOI for Differential DNA methylation of the genes for amyloid precursor protein, tau and neurofilaments in human traumatic brain injury
Visualization of early oligomeric α‐synuclein pathology and its impact on the dopaminergic system in the (Thy‐1)‐h[A30P]α‐syn transgenic mouse model

Behere, Anish; Thörnqvist, Per-Ove; Winberg, Svante; Ingelsson, Martin et al.

Part of Journal of Neuroscience Research, p. 2525-2539, 2021.

DOI for Visualization of early oligomeric α‐synuclein pathology and its impact on the dopaminergic system in the (Thy‐1)‐h[A30P]α‐syn transgenic mouse model Download full text (pdf) of Visualization of early oligomeric α‐synuclein pathology and its impact on the dopaminergic system in the (Thy‐1)‐h[A30P]α‐syn transgenic mouse model

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Multi‐cohort profiling reveals elevated CSF levels of brain‐enriched proteins in Alzheimer’s disease

Bergström, Sofia; Remnestål, Julia; Yousef, Jamil; Olofsson, Jennie et al.

Part of Annals of Clinical and Translational Neurology, p. 1456-1470, 2021.

DOI for Multi‐cohort profiling reveals elevated CSF levels of brain‐enriched proteins in Alzheimer’s disease Download full text (pdf) of Multi‐cohort profiling reveals elevated CSF levels of brain‐enriched proteins in Alzheimer’s disease

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Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid

Boström, Gustaf; Freyhult, Eva; Virhammar, Johan; Alcolea, Daniel et al.

Part of Journal of Alzheimer's Disease, p. 629-640, 2021.

DOI for Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid Download full text (pdf) of Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid

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The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

de la Vega, Maria Pagnon; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena et al.

Part of Science Translational Medicine, 2021.

DOI for The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

de Rojas, Itziar; Moreno-Grau, Sonia; Tesi, Niccolo; Grenier-Boley, Benjamin et al.

Part of Nature Communications, 2021.

DOI for Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores Download full text (pdf) of Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

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Immune cells lacking Y chromosome show dysregulation of autosomal gene expression

Dumanski, Jan P.; Halvardson, Jonatan; Davies, Hanna; Rychlicka-Buniowska, Edyta et al.

Part of Cellular and Molecular Life Sciences (CMLS), p. 4019-4033, 2021.

DOI for Immune cells lacking Y chromosome show dysregulation of autosomal gene expression Download full text (pdf) of Immune cells lacking Y chromosome show dysregulation of autosomal gene expression

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Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Faresjö, Rebecca; Bonvicini, Gillian; Fang, Xiaotian T.; Aguilar, Ximena et al.

Part of Fluids and Barriers of the CNS, 2021.

DOI for Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size Download full text (pdf) of Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

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Last modified: 2023-07-31