Ongoing research projects
Phys-Can (Physical Training and Cancer)
In this multicenter study we evaluate the effects of physical exercise on high or low/moderate intensity in persons undergoing adjuvant cancer treatment, i.e. chemotherapy, radiation and antihormone treatment. Main outcomes are cancer-related fatigue and quality of life, and we perform long-term follow-up on recurrence and survival. In addition, we evaluate the effect of behaviour change support (extra coaching) on performed exercise. Physiological mechanisms are investigated to increase our knowledge about what mediates the effect of exercise on cancer-related fatigue. Health economic evaluations are also performed.
The project is a collaboration between three universities in Sweden: Uppsala, Lund and Linköping, universities of Agder and Bergen in Norway, University of Copenhagen in Denmark, The Netherlands Cancer Institute and VU University Medical Centre vid University of Amsterdam, and University of Leeds, United Kingdom. For more information please contact PI Professor Karin Nordin. For more information plese contact project coordinator Associate Professor Ingrid Demmelmaier
Heavy-load resistance training during chemotherapy for breast cancer
In this study, we aim to investigate the effects of heavy-load resistance training during ongoing chemotherapy on skeletal muscle cellular outcomes. One group of women exercise during treatment and are compared to one non-exercising group. The effects are evaluated by measurement of muscle fiber size and known regulators of muscle fiber size such as myonuclei and satellite cell count. It is already known that chemotherapy may impair both muscle strength and function. In this study we aim to assess if heavy-load resistance training during cancer treatment can counteract such deterioration. Contact: Postdoc Emelie Strandberg
Physical activity and nutrition for patients undergoing stem cell transplantation
This PhD project evaluates the effect of individualized care plans for physical activity and nutrition in patients undergoing stem cell transplantation. Patient experiences are exlored in interviews and qualitative analyses. Contact: PhD student Sölvi Vejby
Stress management in breast cancer
This project focuses primarily on stress symptoms among women recently diagnosed with breast cancer. It is a multicenter intervention study using a stepped care approach focusing on information and a stress management program based on cognitive behavioral therapy. Main outcomes are stress symptoms and psychosocial wellbeing. Health economic evaluations are also performed. The project is funded by the Swedish Cancer Society and the Swedish Research Council (2008-2013) and Uppsala-Örebro Regional Research Council. Contact: Associate Professor Cecilia Arving
Rehabilitation coordinator in specialist healthcare
Two randomized controlled trials are performed to evaluate the effect of introduction of rehabilitation coordinators in healthcare on patients' sick leave and return to work/studies. The results will contribute with new knowledge serving as a base for decisions regarding the rehabilitation coordinator function. One study is performed within psychiatric specialist healthcare and the target group is individuals who are on sick leave due to moderate to severe affective and/or anxiety disorder. This study also uses a qualitative design to explore the patients' perceptions of and experiences from the intervention. Contact: PhD Åsa Andersén. Another study is performed within an orthopaedic clinic, wherre the target group is individuals who are on sick leave for long-term back, foot or shoulder problems. Contact: PhD Erik Berglund.
GESAM - Joint collaboration between the Swedish Social Insurance Agency and the Swedish Public Employment Service
This is a randomized controlled trial consisting of an effect evaluation as well as a process evaluation based on an actor and particpant perspective. The target group is people who have impaired health but no longer have the right to sickness benefit. The effects of a joint collaboration model between the Swedish Social Insurance Agency (SSIA) and the Swedish Public Employment Service (SPES) is evaluated on return to work/studies, participation in the SPES´ activities and return to SSIA. Contact: Associate Professor Ingrid Anderzén.
Young Intro - prehabilitation of young adults with disabilities
This study is a process evalutaion conducted in collaboration with the SSIA, the SPE, the municipality, and the healthcare. The target group is unemplyed young adults with disabilities. The purpose is to study whether the project supports the target group n getting closer to work/studies as well as to identify structural problem in connection with collaboration between the relevant organizations. Another purpose is to identify which methods are used to support the target group. Contact: Associate Professor Kjerstin Larsson
Youths mobilization for the morkplace (UMiA)
This is a long-term follow-up of a project carried out by the SSIA and the SPES during 2012-2014. The target group is young unemployed adults with disabilities, and the aim was to increase their possibilities to enter the labour market. Tho goal of the long-term follow-up is to investigate possible long-term effects of the project, and to evaluate the predictability of a screening tool used to identify individuals at risk of exclusion from the labour market. Contact: PhD Åsa Andersén
VITALIS - Improved health and return to work for people on long-term sick leave
The study is a long-term follow-up of particpants in the VITALIS project, which was a randomized controlled trial conducted in 2010-2012. The target group is women expected to reach their maximum number of paid sick leave days via the SSIA through the regulatory changes that were introduced in 2008. This study evaluates possible long-term effects of the intervention, including a health economic evaluation. Contact: PhD Erik Berglund
FEX-CAN – FERTILITY AND SEXUALITY FOLLOWING CANCER
Fex-Can Young Adult (YA) is a cohort and intervention study to reduce fertility-related distress and sexual dysfunction among young adults (19-40 years) 1.5 year after diagnosis. Participants (N=1010) complete questionnaires and are followed for several years, see study protocol here. Fex-Can Childhood focuses on young adults (19-40 years) who were diagnosed with cancer as children, 2546 survivors participated in a survey study 2019-2020 (response rate 59%), see study protocol here. Both projects evaluate a web-based self-help intervention to alleviate problems/distress, see article here. The program is conducted in cooperation with Karolinska Institutet. External funders include the Swedish Research Council, the Swedish Research Council for Health, Working Life and Welfare, the Swedish Cancer Society, the Swedish Childhood Cancer Foundation. For more information, contact PIs Lena Wettergren and Claudia Lampic.