Research articles

Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function

Konstantinidis, Evangelos; Portal, Benjamin; Mothes, Tobias J.; Beretta, Chiara et al.

Part of Journal of Neuroinflammation, 2023.

DOI for Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function Download full text (pdf) of Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function

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Interleukin-33 inhibits glucose uptake in human adipocytes and its expression in adipose tissue is elevated in insulin resistance and type 2 diabetes.

Pereira, Maria J.; Azim, Ayesha; Hetty, Susanne; Jui Nandi, Bipasha et al.

Part of Cytokine, p. 156080-, 2023.

DOI for Interleukin-33 inhibits glucose uptake in human adipocytes and its expression in adipose tissue is elevated in insulin resistance and type 2 diabetes.
DHA status influences effects of B-vitamin supplementation on cognitive ageing: a post-hoc analysis of the B-proof trial

van Soest, Annick P. M.; van de Rest, Ondine; Witkamp, Renger F.; Cederholm, Tommy et al.

Part of European Journal of Nutrition, p. 3731-3739, 2022.

DOI for DHA status influences effects of B-vitamin supplementation on cognitive ageing: a post-hoc analysis of the B-proof trial Download full text (pdf) of DHA status influences effects of B-vitamin supplementation on cognitive ageing: a post-hoc analysis of the B-proof trial

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A Generalized Transformer-Based Pulse Detection Algorithm

Dematties, Dario; Wen, Chenyu; Zhang, Xiao

Part of ACS Sensors, p. 2710-2720, 2022.

DOI for A Generalized Transformer-Based Pulse Detection Algorithm Download full text (pdf) of A Generalized Transformer-Based Pulse Detection Algorithm

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Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

Julku, Ulrika; Xiong, Mengfei; Wik, Elin; Roshanbin, Sahar et al.

Part of Fluids and Barriers of the CNS, 2022.

DOI for Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis Download full text (pdf) of Brain pharmacokinetics of mono- and bispecific amyloid-beta antibodies in wild-type and Alzheimer's disease mice measured by high cut-off microdialysis

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Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation

Libard, Sylwia; Giedraitis, Vilmantas; Kilander, Lena; Ingelsson, Martin et al.

Part of Journal of Alzheimer's Disease, p. 1601-1614, 2022.

DOI for Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation Download full text (pdf) of Mixed Pathologies in a Subject with a Novel PSEN1 G206R Mutation

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Tissue-based diagnosis of systemic amyloidosis: Experience of the informal diagnostic center at Uppsala University Hospital

Vesterlund Damjanovic, Justina; Ihse, Elisabet; Thelander, Ulrika; Zancanaro, Alice et al.

Part of Upsala Journal of Medical Sciences, 2022.

DOI for Tissue-based diagnosis of systemic amyloidosis: Experience of the informal diagnostic center at Uppsala University Hospital Download full text (pdf) of Tissue-based diagnosis of systemic amyloidosis: Experience of the informal diagnostic center at Uppsala University Hospital

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Implementing precision medicine in a regionally organized healthcare system in Sweden.

Fioretos, Thoas; Wirta, Valtteri; Cavelier, Lucia; Berglund, Eva Caroline et al.

Part of Nature Medicine, p. 1980-1982, 2022.

DOI for Implementing precision medicine in a regionally organized healthcare system in Sweden.
A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

Rofo, Fadi; Meier, Silvio R.; Metzendorf, Nicole G.; Morrison, Jamie et al.

Part of NEUROTHERAPEUTICS, p. 1588-1602, 2022.

DOI for A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice Download full text (pdf) of A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

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Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies

Gorski, Mathias; Rasheed, Humaira; Teumer, Alexander; Thomas, Laurent F. et al.

Part of Kidney International, p. 624-639, 2022.

DOI for Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies Download full text (pdf) of Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies

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Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?

van den Broek, Sara Lopes; Shalgunov, Vladimir; Vazquez, Rocio Garcia; Beschorner, Natalie et al.

Part of Pharmaceuticals, 2022.

DOI for Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible? Download full text (pdf) of Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?

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Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease

Le Guen, Yann; Belloy, Michael E.; Grenier-Boley, Benjamin; de Rojas, Itziar et al.

Part of JAMA Neurology, p. 652-663, 2022.

DOI for Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease
Clinical and societal burden of incident major depressive disorder: A population-wide cohort study in Stockholm

Lundberg, Johan; Cars, Thomas; Loov, Sven-Ake; Soderling, Jonas et al.

Part of Acta Psychiatrica Scandinavica, p. 51-63, 2022.

DOI for Clinical and societal burden of incident major depressive disorder: A population-wide cohort study in Stockholm Download full text (pdf) of Clinical and societal burden of incident major depressive disorder: A population-wide cohort study in Stockholm

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Targeted Gene Therapy to Treat Disorders of the Central Nervous System

Sasikumar, Sanskriti; Ingelsson, Martin

Part of Movement Disorders, p. 892-892, 2022.

DOI for Targeted Gene Therapy to Treat Disorders of the Central Nervous System
Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice

Aniszewska, Agata; Bergström, Joakim; Ingelsson, Martin; Ekmark-Lewén, Sara

Part of Brain and Behavior, 2022.

DOI for Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice Download full text (pdf) of Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice

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Self-reported physical activity and different cardiovascular diseases-Results from updated measurements over 40 years

Lind, Lars; Zethelius, Björn; Byberg, Liisa

Part of PLOS ONE, 2022.

DOI for Self-reported physical activity and different cardiovascular diseases-Results from updated measurements over 40 years Download full text (pdf) of Self-reported physical activity and different cardiovascular diseases-Results from updated measurements over 40 years

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Association of Gonadotropin-Releasing Hormone Agonists for Prostate Cancer With Cardiovascular Disease Risk and Hypertension in Men With Diabetes

Lin, E.; Garmo, Hans; Van Hemelrijck, Mieke; Zethelius, Björn et al.

Part of JAMA Network Open, 2022.

DOI for Association of Gonadotropin-Releasing Hormone Agonists for Prostate Cancer With Cardiovascular Disease Risk and Hypertension in Men With Diabetes Download full text (pdf) of Association of Gonadotropin-Releasing Hormone Agonists for Prostate Cancer With Cardiovascular Disease Risk and Hypertension in Men With Diabetes

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A Clinically Relevant Diagnosis Code for "Malnutrition in Adults" Is Needed in ICD-11

Cederholm, Tommy; Rothenberg, E.; Barazzoni, R.

Part of The Journal of Nutrition, Health & Aging, p. 314-315, 2022.

DOI for A Clinically Relevant Diagnosis Code for "Malnutrition in Adults" Is Needed in ICD-11
Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies

Faresjö, Rebecca; Lindberg, Hanna; Stahl, Stefan; Lofblom, John et al.

Part of Pharmaceutical research, p. 1509-1521, 2022.

DOI for Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies Download full text (pdf) of Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-A beta-Affibodies

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PET Imaging in Preclinical Anti-Aβ Drug Development

Syvänen, Stina; Meier, Silvio R.; Roshanbin, Sahar; Xiong, Mengfei et al.

Part of Pharmaceutical research, p. 1481-1496, 2022.

DOI for PET Imaging in Preclinical Anti-Aβ Drug Development Download full text (pdf) of PET Imaging in Preclinical Anti-Aβ Drug Development

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PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer's disease risk

Lindman, Karin Lopatko; Jonsson, Caroline; Weidung, Bodil; Olsson, Jan et al.

Part of Scientific Reports, 2022.

DOI for PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer's disease risk Download full text (pdf) of PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer's disease risk

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Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

Roshanbin, Sahar; Julku, Ulrika; Xiong, Mengfei; Eriksson, Jonas et al.

Part of Pharmaceutics, 2022.

DOI for Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody Download full text (pdf) of Reduction of alpha SYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody

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Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's A beta amyloidosis

Jiang, Richeng; Smailovic, Una; Haytural, Hazal; Tijms, Betty M. et al.

Part of Acta neuropathologica communications, 2022.

DOI for Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's A beta amyloidosis Download full text (pdf) of Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's A beta amyloidosis

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Professor Margareta Hammarlund-Udenaes: a Modern and Visionary Mentor

Syvänen, Stina; Fridén, Markus

Part of Pharmaceutical research, p. 1291-1296, 2022.

DOI for Professor Margareta Hammarlund-Udenaes: a Modern and Visionary Mentor
Guidance for assessment of the muscle mass phenotypic criterion for the Global Leadership Initiative on Malnutrition (GLIM) diagnosis of malnutrition

Barazzoni, Rocco; Jensen, Gordon L.; Correia, Maria Isabel T. D.; Gonzalez, Maria Cristina et al.

Part of Clinical Nutrition, p. 1425-1433, 2022.

DOI for Guidance for assessment of the muscle mass phenotypic criterion for the Global Leadership Initiative on Malnutrition (GLIM) diagnosis of malnutrition
Amyloid fibril composition type is consistent over time in patients with Val30Met (p.Val50Met) transthyretin amyloidosis

Anan, Intissar; Suhr, Ole B.; Liszewska, Katarzyna; Baranda, Jorge Mejia et al.

Part of PLOS ONE, 2022.

DOI for Amyloid fibril composition type is consistent over time in patients with Val30Met (p.Val50Met) transthyretin amyloidosis Download full text (pdf) of Amyloid fibril composition type is consistent over time in patients with Val30Met (p.Val50Met) transthyretin amyloidosis

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Long-term time trends in reactivated herpes simplex infections and treatment in Sweden

Lopatko Lindman, Karin; Lockman-Lundgren, Judith; Weidung, Bodil; Olsson, Jan et al.

Part of BMC Infectious Diseases, 2022.

DOI for Long-term time trends in reactivated herpes simplex infections and treatment in Sweden Download full text (pdf) of Long-term time trends in reactivated herpes simplex infections and treatment in Sweden

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Comparison of years of life lost to 1,565 suicides versus 10,650 COVID-19 deaths in 2020 in Sweden: four times more years of life lost per suicide than per COVID-19 death

Ljung, Rickard; Grünewald, Maria; Sundström, Anders; Thunander Sundbom, Lena et al.

Part of Upsala Journal of Medical Sciences, 2022.

DOI for Comparison of years of life lost to 1,565 suicides versus 10,650 COVID-19 deaths in 2020 in Sweden: four times more years of life lost per suicide than per COVID-19 death Download full text (pdf) of Comparison of years of life lost to 1,565 suicides versus 10,650 COVID-19 deaths in 2020 in Sweden: four times more years of life lost per suicide than per COVID-19 death

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Dietary supplementation with selenium and coenzyme Q10 prevents increase in plasma D-dimer while lowering cardiovascular mortality in an elderly Swedish population.

Alehagen, Urban; Aaseth, Jan; Lindahl, Tomas L; Larsson, Anders et al.

Part of Nutrition, Exercise, and End-of-LifeDiscussion in the Cardiovascular Field, p. 43-56, 2022.

DOI for Dietary supplementation with selenium and coenzyme Q10 prevents increase in plasma D-dimer while lowering cardiovascular mortality in an elderly Swedish population.

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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Mahajan, Anubha; Spracklen, Cassandra N.; Zhang, Weihua; Ng, Maggie C. Y. et al.

Part of Nature Genetics, p. 560-572, 2022.

DOI for Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation

Konstantinidis, Evangelos; Molisak, Agnieszka; Perrin, Florian; Streubel-Gallasch, Linn et al.

Part of Molecular Therapy - Nucleic Acids, p. 450-461, 2022.

DOI for CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation Download full text (pdf) of CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation

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Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue

Boone, Sebastiaan C.; van Smeden, Maarten; Rosendaal, Frits R.; le Cessie, Saskia et al.

Part of American Journal of Epidemiology, p. 886-899, 2022.

DOI for Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue Download full text (pdf) of Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue

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Function, sarcopenia and osteoporosis 10 years after a femoral neck fracture in patients younger than 70 years

Campenfeldt, Pierre; Al-Ani, Amer; Ekstrom, Wilhelmina; Zeraati, Babak et al.

Part of Injury, p. 1496-1503, 2022.

DOI for Function, sarcopenia and osteoporosis 10 years after a femoral neck fracture in patients younger than 70 years Download full text (pdf) of Function, sarcopenia and osteoporosis 10 years after a femoral neck fracture in patients younger than 70 years

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Advances in the development of new biomarkers for Alzheimer's disease

Klyucherev, Timofey O.; Olszewski, Pawel K.; Shalimova, Alena; Chubarev, Vladimir N. et al.

Part of Translational Neurodegeneration, 2022.

DOI for Advances in the development of new biomarkers for Alzheimer's disease Download full text (pdf) of Advances in the development of new biomarkers for Alzheimer's disease

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Intake of Ultra-Processed Food and Ectopic-, Visceral- and Other Fat Depots: A Cross-Sectional Study.

Fridén, Michael; Kullberg, Joel; Ahlström, Håkan; Lind, Lars et al.

Part of Frontiers in nutrition, 2022.

DOI for Intake of Ultra-Processed Food and Ectopic-, Visceral- and Other Fat Depots: A Cross-Sectional Study. Download full text (pdf) of Intake of Ultra-Processed Food and Ectopic-, Visceral- and Other Fat Depots: A Cross-Sectional Study.

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In vivo imaging of alpha-synuclein with antibody-based PET

Roshanbin, Sahar; Xiong, Mengfei; Hultqvist, Greta; Soderberg, Linda et al.

Part of Neuropharmacology, 2022.

DOI for In vivo imaging of alpha-synuclein with antibody-based PET Download full text (pdf) of In vivo imaging of alpha-synuclein with antibody-based PET

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Fatty acids in multiple circulating lipid fractions reflects the composition of liver triglycerides in humans

Rosqvist, Fredrik; Fridén, Michael; Vessby, Johan; Hockings, Paul et al.

Part of Clinical Nutrition, p. 805-809, 2022.

DOI for Fatty acids in multiple circulating lipid fractions reflects the composition of liver triglycerides in humans Download full text (pdf) of Fatty acids in multiple circulating lipid fractions reflects the composition of liver triglycerides in humans

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PET-CT imaging of pulmonary inflammation using [Ga-68]Ga-DOTA-TATE

Puuvuori, Emmi; Liggieri, Francesco; Velikyan, Irina; Chiodaroli, Elena et al.

Part of EJNMMI Research, 2022.

DOI for PET-CT imaging of pulmonary inflammation using [Ga-68]Ga-DOTA-TATE Download full text (pdf) of PET-CT imaging of pulmonary inflammation using [Ga-68]Ga-DOTA-TATE

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New insights into the genetic etiology of Alzheimer's disease and related dementias

Bellenguez, Celine; Giedraitis, Vilmantas; Ingelsson, Martin; Lambert, Jean-Charles

Part of Nature Genetics, p. 412-436, 2022.

DOI for New insights into the genetic etiology of Alzheimer's disease and related dementias Download full text (pdf) of New insights into the genetic etiology of Alzheimer's disease and related dementias

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Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

Rofo, Fadi; Metzendorf, Nicole; Saubi, Cristina; Suominen, Laura et al.

Part of Alzheimer's Research & Therapy, 2022.

DOI for Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease Download full text (pdf) of Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

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Milk and Fermented Milk Consumption and Risk of Stroke: Longitudinal Study

Olsson, Erika; Larsson, Susanna C.; Höijer, Jonas; Kilander, Lena et al.

Part of Nutrients, 2022.

DOI for Milk and Fermented Milk Consumption and Risk of Stroke: Longitudinal Study Download full text (pdf) of Milk and Fermented Milk Consumption and Risk of Stroke: Longitudinal Study

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Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping

Belloy, Michael E.; Eger, Sarah J.; Le Guen, Yann; Damotte, Vincent et al.

Part of Alzheimer's Research & Therapy, 2022.

DOI for Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping Download full text (pdf) of Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping

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Feasibility of PURPOSE T in clinical practice and patient participation – a mixed-method study

Hultin, Lisa; Karlsson, Ann-Christin; Löwenmark, Malin; Coleman, Susanne et al.

Part of International Wound Journal, 2022.

DOI for Feasibility of PURPOSE T in clinical practice and patient participation – a mixed-method study

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Single Point Insulin Sensitivity Estimator in Pediatric Non-Alcoholic Fatty Liver Disease

Furthner, Dieter; Anderwald, Christian-Heinz; Bergsten, Peter; Forslund, Anders et al.

Part of Frontiers in Endocrinology, 2022.

DOI for Single Point Insulin Sensitivity Estimator in Pediatric Non-Alcoholic Fatty Liver Disease Download full text (pdf) of Single Point Insulin Sensitivity Estimator in Pediatric Non-Alcoholic Fatty Liver Disease

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Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies

Bjorvang, Richelle D.; Hallberg, Ida; Pikki, Anne; Berglund, Lars et al.

Part of Environmental Research, 2022.

DOI for Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies Download full text (pdf) of Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies

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Serum levels of perfluoroalkyl substances (PFAS) and body composition - A cross-sectional study in a middle-aged population

Lind, P. Monica; Lind, Lars; Salihovic, Samira; Ahlström, Håkan et al.

Part of Environmental Research, p. 112677-, 2022.

DOI for Serum levels of perfluoroalkyl substances (PFAS) and body composition - A cross-sectional study in a middle-aged population Download full text (pdf) of Serum levels of perfluoroalkyl substances (PFAS) and body composition - A cross-sectional study in a middle-aged population

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Blood pressure screening in midlife aids in prediction of dementia later in life

Moberg, Lena; Leppert, Jerzy; Liljeström, Simon; Rehn, Mattias et al.

Part of Upsala Journal of Medical Sciences, 2022.

DOI for Blood pressure screening in midlife aids in prediction of dementia later in life Download full text (pdf) of Blood pressure screening in midlife aids in prediction of dementia later in life

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CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage?

Pereira, Maria J.; Vranic, Milica; Kamble, Prasad G.; Jernow, Henning et al.

Part of Translational Research, p. 105-121, 2022.

DOI for CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage? Download full text (pdf) of CDKN2C expression in adipose tissue is reduced in type II diabetes and central obesity: impact on adipocyte differentiation and lipid storage?

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Inflammation as a diagnostic criterion in the GLIM definition of malnutrition-what CRP-threshold relates to reduced food intake in older patients with acute disease?

Pourhassan, Maryam; Cederholm, Tommy; Trampisch, Ulrike; Volkert, Dorothee et al.

Part of European Journal of Clinical Nutrition, p. 397-400, 2022.

DOI for Inflammation as a diagnostic criterion in the GLIM definition of malnutrition-what CRP-threshold relates to reduced food intake in older patients with acute disease? Download full text (pdf) of Inflammation as a diagnostic criterion in the GLIM definition of malnutrition-what CRP-threshold relates to reduced food intake in older patients with acute disease?

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Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia

Pagnon de la Vega, María; Näslund, Carl; Brundin, RoseMarie; Lannfelt, Lars et al.

Part of BMC Genomics, 2022.

DOI for Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia Download full text (pdf) of Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer’s disease and frontotemporal dementia

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¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

Meier, Silvio R.; Sehlin, Dag; Roshanbin, Sahar; Lim Falk, Victoria et al.

Part of Journal of Nuclear Medicine, p. 302-309, 2022.

DOI for ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention Download full text (pdf) of ¹¹C-PiB and ¹²⁴I-antibody PET provide differing estimates of brain amyloid-β after therapeutic intervention

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Passive and receptor mediated brain delivery of an anti-GFAP nanobody

Meier, Silvio R.; Sehlin, Dag; Syvänen, Stina

Part of Nuclear Medicine and Biology, p. 128-134, 2022.

DOI for Passive and receptor mediated brain delivery of an anti-GFAP nanobody Download full text (pdf) of Passive and receptor mediated brain delivery of an anti-GFAP nanobody

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Amyloid, tau, and astrocyte pathology in autosomal-dominant Alzheimer's disease variants: A beta PParc and PSEN1DE9

Lemoine, Laetitia; Gillberg, Per-Goran; Bogdanovic, Nenad; Nennesmo, Inger et al.

Part of Molecular Psychiatry, p. 5609-5619, 2021.

DOI for Amyloid, tau, and astrocyte pathology in autosomal-dominant Alzheimer's disease variants: A beta PParc and PSEN1DE9 Download full text (pdf) of Amyloid, tau, and astrocyte pathology in autosomal-dominant Alzheimer's disease variants: A beta PParc and PSEN1DE9

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The Amyloid-beta Pathway in Alzheimer's Disease

Hampel, Harald; Hardy, John; Blennow, Kaj; Chen, Christopher et al.

Part of Molecular Psychiatry, p. 5481-5503, 2021.

DOI for The Amyloid-beta Pathway in Alzheimer's Disease Download full text (pdf) of The Amyloid-beta Pathway in Alzheimer's Disease

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Traumatic brain injury in the presence of Aβ pathology affects neuronal survival, glial activation and autophagy

Streubel-Gallasch, Linn; Zyśk, Marlena; Beretta, Chiara; Erlandsson, Anna

Part of Scientific Reports, 2021.

DOI for Traumatic brain injury in the presence of Aβ pathology affects neuronal survival, glial activation and autophagy Download full text (pdf) of Traumatic brain injury in the presence of Aβ pathology affects neuronal survival, glial activation and autophagy

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Lack of fibrillar amyloid plaques but hypometabolism and astrogliosis in autosomal dominant variant AssPParc Alzheimer's disease

Lemoine, Laetitia; Gillberg, Per-Goran; Bogdanovic, Nenad; Nennesmo, Inger et al.

Part of Molecular Psychiatry, p. 5471-5471, 2021.

DOI for Lack of fibrillar amyloid plaques but hypometabolism and astrogliosis in autosomal dominant variant AssPParc Alzheimer's disease
A comparative study on Suzuki‐type 11 C‐methylation of aromatic organoboranes performed in two reaction media

Rokka, Johanna; Nordeman, Patrik; Bergman, Sara; Eriksson, Jonas

Part of Journal of labelled compounds & radiopharmaceuticals, p. 447-455, 2021.

DOI for A comparative study on Suzuki‐type 11 C‐methylation of aromatic organoboranes performed in two reaction media Download full text (pdf) of A comparative study on Suzuki‐type 11 C‐methylation of aromatic organoboranes performed in two reaction media

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Antiviral treatment associated with reduced risk of clinical Alzheimer's disease: A nested case‐control study

Hemmingsson, Eva‐Stina; Hjelmare, Ellen; Weidung, Bodil; Olsson, Jan et al.

Part of Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2021.

DOI for Antiviral treatment associated with reduced risk of clinical Alzheimer's disease: A nested case‐control study Download full text (pdf) of Antiviral treatment associated with reduced risk of clinical Alzheimer's disease: A nested case‐control study

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Herpesvirus infections, antiviral treatment, and the risk of dementia: a registry‐based cohort study in Sweden

Lopatko Lindman, Karin; Hemmingsson, Eva‐Stina; Weidung, Bodil; Brännström, Jon et al.

Part of Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2021.

DOI for Herpesvirus infections, antiviral treatment, and the risk of dementia: a registry‐based cohort study in Sweden Download full text (pdf) of Herpesvirus infections, antiviral treatment, and the risk of dementia: a registry‐based cohort study in Sweden

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Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

de Rojas, Itziar; Moreno-Grau, Sonia; Tesi, Niccolo; Grenier-Boley, Benjamin et al.

Part of Nature Communications, 2021.

DOI for Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores Download full text (pdf) of Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

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Neuromuscular controller models for quantifying standing balance in older people: A systematic review

Olsson, Fredrik; Halvorsen, Kjartan; Åberg, Anna Cristina

Part of IEEE Reviews in Biomedical Engineering, p. 1-1, 2021.

DOI for Neuromuscular controller models for quantifying standing balance in older people: A systematic review
Multi‐cohort profiling reveals elevated CSF levels of brain‐enriched proteins in Alzheimer’s disease

Bergström, Sofia; Remnestål, Julia; Yousef, Jamil; Olofsson, Jennie et al.

Part of Annals of Clinical and Translational Neurology, p. 1456-1470, 2021.

DOI for Multi‐cohort profiling reveals elevated CSF levels of brain‐enriched proteins in Alzheimer’s disease Download full text (pdf) of Multi‐cohort profiling reveals elevated CSF levels of brain‐enriched proteins in Alzheimer’s disease

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The genomics of heart failure: design and rationale of the HERMES consortium

Lumbers, R. Thomas; Shah, Sonia; Lin, Honghuang; Czuba, Tomasz et al.

Part of ESC Heart Failure, p. 5531-5541, 2021.

DOI for The genomics of heart failure: design and rationale of the HERMES consortium Download full text (pdf) of The genomics of heart failure: design and rationale of the HERMES consortium

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Decreased Mortality Over Time During the First Wave in Patients With COVID-19 in Geriatric Care: Data From the Stockholm GeroCovid Study.

Xu, Hong; Garcia-Ptacek, Sara; Annetorp, Martin; Cederholm, Tommy et al.

Part of Journal of the American Medical Directors Association, p. 1565-1573, 2021.

DOI for Decreased Mortality Over Time During the First Wave in Patients With COVID-19 in Geriatric Care: Data From the Stockholm GeroCovid Study. Download full text (pdf) of Decreased Mortality Over Time During the First Wave in Patients With COVID-19 in Geriatric Care: Data From the Stockholm GeroCovid Study.

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Astroglial tracer BU99008 detects multiple binding sites in Alzheimer’s disease brain

Kumar, Amit; Koistinen, Niina A.; Malarte, Mona-Lisa; Nennesmo, Inger et al.

Part of Molecular Psychiatry, p. 5833-5847, 2021.

DOI for Astroglial tracer BU99008 detects multiple binding sites in Alzheimer’s disease brain Download full text (pdf) of Astroglial tracer BU99008 detects multiple binding sites in Alzheimer’s disease brain

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Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19

Kananen, L; Eriksdotter, M; Boström, A M; Kivipelto, M et al.

Part of Clinical Nutrition, 2021.

DOI for Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19 Download full text (pdf) of Body mass index and Mini Nutritional Assessment-Short Form as predictors of in-geriatric hospital mortality in older adults with COVID-19

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Circulating fatty acids in patients with head and neck cancer after treatment: an explorative study with a one-year perspective

Christou, Constantina; Ehrsson, Ylva Tiblom; Lampa, Erik; Risérus, Ulf et al.

Part of Acta Oto-Laryngologica, p. 878-884, 2021.

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Large-Scale Plasma Protein Profiling of Incident Myocardial Infarction, Ischemic Stroke, and Heart Failure

Lind, Lars; Zanetti, Daniela; Ingelsson, Martin; Gustafsson, Stefan et al.

Part of Journal of the American Heart Association, 2021.

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ABBV-0805, a novel antibody selective for soluble aggregated alpha-synuclein, prolongs lifespan and prevents buildup of alpha-synuclein pathology in mouse models of Parkinson's disease

Nordström, Eva; Eriksson, Fredrik; Sigvardson, Jessica; Johannesson, Malin et al.

Part of Neurobiology of Disease, 2021.

DOI for ABBV-0805, a novel antibody selective for soluble aggregated alpha-synuclein, prolongs lifespan and prevents buildup of alpha-synuclein pathology in mouse models of Parkinson's disease Download full text (pdf) of ABBV-0805, a novel antibody selective for soluble aggregated alpha-synuclein, prolongs lifespan and prevents buildup of alpha-synuclein pathology in mouse models of Parkinson's disease

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Sarcopenia and malnutrition in relation to mortality in hospitalised patients in geriatric care - predictive validity of updated diagnoses

Sobestiansky, Sigvard; Åberg, Anna Cristina; Cederholm, Tommy

Part of Clinical Nutrition ESPEN, p. 442-448, 2021.

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Exploring the association between use of gonadotropin releasing hormones agonists and prostate cancer diagnosis per se and diabetes control in men with type 2 diabetes mellitus: a nationwide, population-based cohort study

Lin, E.; Garmo, Hans; Van Hemelrijck, Mieke; Adolfsson, Jan et al.

Part of BMC Cancer, 2021.

DOI for Exploring the association between use of gonadotropin releasing hormones agonists and prostate cancer diagnosis per se and diabetes control in men with type 2 diabetes mellitus: a nationwide, population-based cohort study Download full text (pdf) of Exploring the association between use of gonadotropin releasing hormones agonists and prostate cancer diagnosis per se and diabetes control in men with type 2 diabetes mellitus: a nationwide, population-based cohort study

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Second Consensus on Treatment of Patients Recently Diagnosed with Mild Hypertension and Low Cardiovascular Risk (vol 45, 100653, 2020)

Morales-Salinas, A.; Olsen, M. H.; Kones, R.; Kario, K. et al.

Part of Current problems in cardiology, 2021.

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Assessment of requests for medication-related follow-up after hospital discharge, and the relation to unplanned hospital revisits, in older patients: a multicentre retrospective chart review

Cam, Henrik; Kempen, Thomas Gerardus Hendrik; Eriksson, Helena; Abdulreda, Kanar et al.

Part of BMC Geriatrics, 2021.

DOI for Assessment of requests for medication-related follow-up after hospital discharge, and the relation to unplanned hospital revisits, in older patients: a multicentre retrospective chart review Download full text (pdf) of Assessment of requests for medication-related follow-up after hospital discharge, and the relation to unplanned hospital revisits, in older patients: a multicentre retrospective chart review

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Relative and Absolute Risk to Guide the Management of Pulse Pressure, an Age-Related Cardiovascular Risk Factor

Melgarejo, Jesus D.; Thijs, Lutgarde; Wei, Dong-Mei; Bursztyn, Michael et al.

Part of American Journal of Hypertension, p. 929-938, 2021.

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Isolated Diastolic Hypertension in the IDACO Study: An Age-Stratified Analysis Using 24-Hour Ambulatory Blood Pressure Measurements

McEvoy, John W.; Yang, Wen-Yi; Thijs, Lutgarde; Zhang, Zhen-Yu et al.

Part of Hypertension, p. 1222-1231, 2021.

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Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Rofo, Fadi; Buijs, Jos; Falk, Ronny; Honek, Ken et al.

Part of Translational Neurodegeneration, 2021.

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Extraction of gait parameters from marker-free video recordings of Timed Up-and-Go tests: Validity, inter- and intra-rater reliability

Åberg, Anna Cristina; Olsson, Fredrik; Åhman, Hanna Bozkurt; Tarassova, Olga et al.

Part of Gait & Posture, p. 489-495, 2021.

DOI for Extraction of gait parameters from marker-free video recordings of Timed Up-and-Go tests: Validity, inter- and intra-rater reliability Download full text (pdf) of Extraction of gait parameters from marker-free video recordings of Timed Up-and-Go tests: Validity, inter- and intra-rater reliability

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Impact of risk factors for major cardiovascular diseases: a comparison of life-time observational and Mendelian randomisation findings

Lind, Lars; Ingelsson, Martin; Sundström, Johan; Ärnlöv, Johan

Part of Open heart, 2021.

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Visualization of early oligomeric α‐synuclein pathology and its impact on the dopaminergic system in the (Thy‐1)‐h[A30P]α‐syn transgenic mouse model

Behere, Anish; Thörnqvist, Per-Ove; Winberg, Svante; Ingelsson, Martin et al.

Part of Journal of Neuroscience Research, p. 2525-2539, 2021.

DOI for Visualization of early oligomeric α‐synuclein pathology and its impact on the dopaminergic system in the (Thy‐1)‐h[A30P]α‐syn transgenic mouse model Download full text (pdf) of Visualization of early oligomeric α‐synuclein pathology and its impact on the dopaminergic system in the (Thy‐1)‐h[A30P]α‐syn transgenic mouse model

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Scored-GLIM as an effective tool to assess nutrition status and predict survival in patients with cancer

Zhang, Qi; Zhang, Kang-Ping; Zhang, Xi; Tang, Meng et al.

Part of Clinical Nutrition, p. 4225-4233, 2021.

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Changes in leisure-time physical activity during the adult life span and relations to cardiovascular risk factors-Results from multiple Swedish studies

Lind, Lars; Zethelius, Björn; Lindberg, Eva; Pedersen, Nancy L. et al.

Part of PLOS ONE, 2021.

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In vivo imaging of synaptic density with [C-11]UCB-J PET in two mouse models of neurodegenerative disease

Xiong, Mengfei; Roshanbin, Sahar; Rokka, Johanna; Schlein, Eva et al.

Part of NeuroImage, 2021.

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Association between open-angle glaucoma and Alzheimer's disease in Sweden: a long-term population-based follow-up study

Ekström, Curt; Puhto, Ida; Kilander, Lena

Part of Upsala Journal of Medical Sciences, 2021.

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Swedish Covid-19 Investigation for Future Insights-A Population Epidemiology Approach Using Register Linkage (SCIFI-PEARL)

Nyberg, Fredrik; Franzen, Stefan; Lindh, Magnus; Vanfleteren, Lowie et al.

Part of Clinical Epidemiology, p. 649-659, 2021.

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The existence of A beta strains and their potential for driving phenotypic heterogeneity in Alzheimer's disease

Lau, Heather H. C.; Ingelsson, Martin; Watts, Joel C.

Part of Acta Neuropathologica, p. 17-39, 2021.

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Dietary fat intakes and cardiovascular disease risk in adults with type 2 diabetes: a systematic review and meta-analysis

Schwab, Ursula; Reynolds, Andrew N.; Sallinen, Taisa; Rivellese, Angela Albarosa et al.

Part of European Journal of Nutrition, p. 3355-3363, 2021.

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Parkinson's Disease-Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance

Streubel-Gallasch, Linn; Giusti, Veronica; Sandre, Michele; Tessari, Isabella et al.

Part of Molecular Neurobiology, p. 3119-3140, 2021.

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A year with the GLIM diagnosis of malnutrition: does it work for older persons?

Cederholm, Tommy; Barazzoni, Rocco

Part of Current opinion in clinical nutrition and metabolic care, p. 4-9, 2021.

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The Uppsala APP deletion causes early onset autosomal dominant Alzheimer's disease by altering APP processing and increasing amyloid beta fibril formation

de la Vega, Maria Pagnon; Giedraitis, Vilmantas; Michno, Wojciech; Kilander, Lena et al.

Part of Science Translational Medicine, 2021.

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Imaging features associated with idiopathic normal pressure hydrocephalus have high specificity even when comparing with vascular dementia and atypical parkinsonism

Fällmar, David; Andersson, Oliver; Kilander, Lena; Löwenmark, Malin et al.

Part of Fluids and Barriers of the CNS, 2021.

DOI for Imaging features associated with idiopathic normal pressure hydrocephalus have high specificity even when comparing with vascular dementia and atypical parkinsonism Download full text (pdf) of Imaging features associated with idiopathic normal pressure hydrocephalus have high specificity even when comparing with vascular dementia and atypical parkinsonism

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Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

Rofo, Fadi; Sandbaumhüter, Friederike A.; Chourlia, Aikaterini; Metzendorf, Nicole G. et al.

Part of ACS Chemical Neuroscience, p. 2529-2541, 2021.

DOI for Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide Download full text (pdf) of Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

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Elevated soluble amyloid beta protofibrils in Down syndrome and Alzheimer's disease

Johannesson, Malin; Sahlin, Charlotte; Söderberg, Linda; Basun, Hans et al.

Part of Molecular and Cellular Neuroscience, 2021.

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Timed “Up & Go” Dual-Task Tests: Age- and Sex-Specific Reference Values and Test-Retest Reliability in Cognitively Healthy Controls

Åhman, Hanna Bozkurt; Berglund, Lars; Cedervall, Ylva; Giedraitis, Vilmantas et al.

Part of Physical Therapy, 2021.

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Different Inflammatory Signatures in Alzheimer's Disease and Frontotemporal Dementia Cerebrospinal Fluid

Boström, Gustaf; Freyhult, Eva; Virhammar, Johan; Alcolea, Daniel et al.

Part of Journal of Alzheimer's Disease, p. 629-640, 2021.

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Leukocytes with chromosome Y loss have reduced abundance of the cell surface immunoprotein CD99

Mattisson, Jonas; Danielsson, Marcus; Hammond, Maria; Davies, Hanna et al.

Part of Scientific Reports, 2021.

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A screening method to spot biomarkers that may warn of serious events in a chronic disease - illustrated by cardiological CLARICOR trial data.

Winkel, Per; Hilden, Jørgen; Jakobsen, Janus Christian; Lindschou, Jane et al.

Part of Clinical Chemistry and Laboratory Medicine, p. 1852-1860, 2021.

DOI for A screening method to spot biomarkers that may warn of serious events in a chronic disease - illustrated by cardiological CLARICOR trial data.

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Adapting a guided low-intensity behavioural activation intervention for people with dementia and depression in the Swedish healthcare context (INVOLVERA): a study protocol using codesign and participatory action research

Svedin, Frida; Brantnell, Anders; Farrand, Paul; Blomberg, Oscar et al.

Part of BMJ Open, 2021.

DOI for Adapting a guided low-intensity behavioural activation intervention for people with dementia and depression in the Swedish healthcare context (INVOLVERA): a study protocol using codesign and participatory action research Download full text (pdf) of Adapting a guided low-intensity behavioural activation intervention for people with dementia and depression in the Swedish healthcare context (INVOLVERA): a study protocol using codesign and participatory action research

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Women with Fibromyalgia Prefer Resistance Exercise with Heavy Load: A Randomized Crossover Pilot Study

Andersson, Ulf Mathias; Åberg, Anna Cristina; von Koch, Lena; Palstam, Annie

Part of International Journal of Environmental Research and Public Health, 2021.

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Blood pressure-lowering treatment for the prevention of cardiovascular events in patients with atrial fibrillation: An individual participant data meta-analysis

Pinho-Gomes, Ana-Catarina; Azevedo, Luis; Copland, Emma; Canoy, Dexter et al.

Part of PLoS Medicine, 2021.

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Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Faresjö, Rebecca; Bonvicini, Gillian; Fang, Xiaotian T.; Aguilar, Ximena et al.

Part of Fluids and Barriers of the CNS, 2021.

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