Contact: Geriatrics research group leader Stina Syvänen
Visiting address: Dag Hammarskjölds väg 20, Uppsala Science Park
The aim of our research is to understand, prevent, diagnos and cure diseases in the elderly population, like dementia, diabetes and cardiovascular diease.
In clinical trials we develop new drugs against these diseases. We are conducting epidemiological and genetic studies to understand the interplay between genes and environment in complex disorders. In clinical research we aim to develop better diagnostic instruments for Alzheimer’s disease. Our molecular research is aiming at disease mechanisms of Alzheimer’s disease and related disorders. The starting point for these studies is genetic discoveries to understand molecular mechanisms involved in dementias. Model systems have been developed in transgenic animals and in cell cultures to test new treatment principles.
Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function
Causal analysis of plasma IL-8 on carotid intima media thickness, a measure of subclinical atherosclerosis
The metabolic profile of waist to hip ratio-A multi-cohort study
Ex‘PLA’ining the progression of pathological proteins in Alzheimer’s and Parkinson’s diseases: see(d)ing is believing.
Evangelos Konstantinidis (2022)
CRISPR/Cas9-based therapies and the role of astrocytes in Alzheimer’s disease and Parkinson’s disease.
Tobias Gustavsson (2022)
Brain distribution of a bispecific antibody targeting Aβ.
Hanna Bozkurt Åhman (2021)
Timed Up-and-Go Dual-Task Tests for Early Detection of Dementia Disorder.