News at IFV
Most of our news are in swedish.
Groundbreaking research on Alzheimer’s disease
2022-10-19
This autumn saw one of the biggest breakthroughs of all time in Alzheimer’s research. At this year’s Olof Rudbeck Day on 21 October, Olof Rudbeck Award winner Lars Lannfelt, Senior Consultant and Professor Emeritus of Geriatrics at Uppsala University, will lecture on the research into the new drug candidate.

Early in his career, Lars Lannfelt started researching diseases with heredity and mechanisms of disease development. He obtained his PhD in 1990 on the disease Acute Intermittent Porphyria, which gave him a good foundation in genetics and biochemistry. Soon after, Lars found a genetic change in a large family with Alzheimer’s disease in central Sweden. It was a major scientific breakthrough that became known as the Swedish mutation.
“In a single family, we were able to get a snapshot of how the disease could develop,” says Lars. “The hereditary changes are extremely rare but have great value in explaining the disease in general.”
A few years later, a general practitioner in Umeå contacted Lars about a family in the northernmost part of Sweden with many cases of dementia. Lars and his research team found a mutation with specific characteristics that was the cause of the disease in the family. The variation was named the Arctic mutation and would become the basis for the future new medicine.
“I was very interested when we found a special form of the harmful substance amyloid beta in the plaques of this family. The special form was a soluble precursor to the insoluble, long threads, the fibrils, found in plaques. It was then, in 1999, that I had the idea of attacking the precursor to the fibrils with antibodies.”
A gratifying announcement
Twenty years later, the last clinical trial was completed showing that the antibody lecanemab slows clinical deterioration in patients with Alzheimer’s disease. The drug could be the first to target the cause of the disease – not the symptoms. The study was conducted by the pharmaceutical company Eisai in collaboration with BioArctic, which Lars founded.
“The results are clear with strong statistical significance, and all primary and secondary endpoints were met,” Lars clarifies. “This is gratifying and incredibly important for Alzheimer’s research.
“The next step is to apply to the US, Japanese and European drug agencies. An approved drug is probably ready by 2024 and slightly earlier in the US. For patients, we now have a chance to slow down the progression. To what extent remains to be seen, but we are very optimistic,” says Lars.
From mutation to possible treatment for Alzheimer’s disease
Lars’ curiosity and desire to understand the molecular mechanisms behind neurodegenerative diseases have been his driving force over the years. He will talk about this at this year’s Olof Rudbeck Day, as the recipient of the 2021 Olof Rudbeck Prize, during his lecture "From mutation to possible treatment of Alzheimer’s disease".
“I have been enormously stubborn and convinced that we have been on the right track,” says Lars. “But to get good results, it’s important to surround yourself with talented collaborators, which I’ve had over the years. My wish is that we will eventually be able to completely stop the disease process in Alzheimer’s disease – especially when we get in really early in the treatment process.
“Olof Rudbeck Day is a whole day focused on the brain and dementia, and I hope that this day will give hope to those affected and their families,” concludes Lars Lannfelt.
Text: Cecilia Yates
Find out more
Lars Lannfelt’s research group
BioArctic
Rudbeck Day 2022: When the brain no longer complies – is it dementia?
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Lena Wettergren is awarded Region Uppsala’s research prize 2022
2023-06-07
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Innovation inom den gotländska hälso- och sjukvården - Innovationssystem Gotland
2023-05-03
De senaste åren har det arbetats systematiskt med innovation inom den gotländska hälso- och sjukvården genom projektet Innovationssystem Gotland. Anna Sarkadi, Professor vid Institutionen för folkhälso- och vårdvetenskap, har varit senior rådgivare till projektet.
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New compilation of knowledge published about the work environment for healthcare personnel during the corona pandemic
2023-04-27
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Certificate of recognition to the professors Ulrika Winblad and Paula Blomqvist
2023-04-21
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New SNS-report on collaboration in multimorbidity among older adults
2023-04-18
I en nyligen utgiven SNS-rapport har Ulrika Winblad, professor i hälso- och sjukvårdsforskning, och Paula Blomqvist, professor i statsvetenskap, sammanfattat forskningsfältet för samverkan inom äldreomsorgen. Författarna framhäver vikten av samordning mellan regioner och kommuner för en god vård av multisjuka äldre samt ett behov av att tydliggöra den statliga styrningen av samverkan.
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Dagens Medicin Debatt: ”Barnhälsovården kan stå modell för kunskapsstyrningen”
2023-04-17
Anna Sarkadi medverkadi i Dagens Medicin debatt.
Debattens ämne: "Med en lång tradition av arbete med kunskapsstöd, dataanalys och verksamhetsutveckling är barnhälsovården värd att ta efter, skriver tre debattörer." (Källa: DM) -
Successful collaboration in Gotland’s healthcare sector
2023-03-31
In recent years, systematic innovation work has been conducted in Gotland’s healthcare sector through the Innovation System Gotland project. The project is part of the University’s strategic partnership with the Gotland Region. Innovationssystem Gotland (Innovation System Gotland) is an exciting example of how successful collaboration can be achieved, in this case between academia, the healthcare sector and Science Park Gotland.
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Report mapping the Borgholm model
2023-03-13
The work report was written in collaboration between the research groups Health Service Research and CHAP. The report is an overview of the different working methods at the health center in Borgholm. The purpose was to map the Borgholm model before an economic evaluation examines the actual effects. The report is written by Sébastien Lindhagen, Inna Feldman and Ulrika Winblad.
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Små barns tankar om pandemin
2023-03-06
Forskare från Uppsala universitet har studerat teckningar med coronamotiv målade av barn mellan fyra till sex år. Resultatet visar att även yngre barn påverkades påtagligt av pandemin. Se artiklarna om forskningen och videon med barnens berätterlse och teckningar.
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Early actions can prevent gang shootings
2023-03-02
Research shows that only a small proportion of parents take advantage of the effective parenting support programmes that exist for children with disruptive behavioural problems. Read Anna Sarkadis view of society today and the current shootings that have increased during the 2020s in Sweden.
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”Anpassa digitala medier efter barn, inte tvärtom”
2023-02-06
"Varför ska barn och unga anpassa sig till den digitala världen, hur beroendeframkallande, laglös och skruvad den än är? Skärp i stället reglerna för digitala plattformar, skriver flera debattörer." SvD
Anna Sarkadi, vår gruppledare bidrog i denna debattartikel. -
PHD Course March 2023, Migration and Health
2023-01-13
Conducting research with migrant populations, 4.5 hp.
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Medel från Vetenskapsrådet beviljat för att etablera en ny forskarskola: ”Mälardalsområdets forskarskola i vårdvetenskap”.
2022-12-15
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Portrait of Professor Ulrika Winblad in journal about elderly care
2022-12-13
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New model to help families with children with everyday finances - Härnösand Municipality
2022-11-24
"Healthier Wealthier Families" has been started in Härnösand municipality.
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Internationella trycksårsdagen - Reportage med Lisa Hultin
2022-11-17
Tidningen Vårdfokus har skrivit ett reportage med Lisa Hultin, Specialistsjuksköterska och Universitetsadjunkt i forskargruppen Vårdvetenskap.
"I dag är det internationella trycksårsdagen, en dag då vårdens professioner uppmuntras att ha extra fokus på arbetet med att förebygga, upptäcka och behandla de skador som uppstår när huden utsätts för tryck eller förskjutning, så kallad skjuv.Det är en viktig dag tycker specialistsjuksköterskan Lisa Hultin. För trots att kunskapen om varför trycksår uppstår och hur de kan förebyggas utvecklar var sjunde inneliggande patient trycksår på svenska sjukhus."
Text: Sanna Björkman -
Vår utvärdering i Skäggetorp i nyheterna
2022-11-14
Vår utvärdering i Skäggetorp var i nyheterna i Lokala Nyheter Öst.
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Research environmental support to study the new welfare market in Sweden
2022-11-14
Professor Ulrika Winblad at the Department of Public Health and Care Sciences has recently been granted almost SEK 17.5 million in environmental support from the Swedish Research Council for the application The new welfare markets in Sweden - how is social equality affected? The research will last for six years and is a collaboration between researchers at the Faculty of Medicine and the Faculty of Social Sciences at Uppsala University, more specifically the Department of Public Health and Care Sciences, the Department of Political Science and the Department of Business Economics. The collaboration also includes researchers from the University of Bergen in Norway and the University of Copenhagen in Denmark. Co-applicant researchers are Associate Professor Paula Blomqvist, Associate Professor Mio Fredriksson, Professor Josef Pallas, PhD Linda Moberg, Professor Karsten Vrangbæk, and Professor Oddvar Kaarboe.
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Anslag från VR till medarbetare på institutionen!
2022-11-09
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Malin Lohela Karlsson receives funds to evaluate methods for improved work environment and patient safety
2022-10-20
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Groundbreaking research on Alzheimer’s disease
2022-10-19
This autumn saw one of the biggest breakthroughs of all time in Alzheimer’s research. At this year’s Olof Rudbeck Day on 21 October, Olof Rudbeck Award winner Lars Lannfelt, Senior Consultant and Professor Emeritus of Geriatrics at Uppsala University, will lecture on the research into the new drug candidate.
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Members of the group for Health Services Research participate in Radio Sweden
2022-09-30
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Ulrika Winblad in media about nationalizing healthcare and future eldercare
2022-09-27
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Pulverdiet och nya kostvanor kan få typ 2-diabetes att vända
2022-09-27
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María Pagnon de la Vega is awarded the Hwasser prize for best PhD thesis 2021/2022.
2022-09-20
María Pagnon de la Vega receives the prize for her thesis, Characterization of the novel “Uppsala mutation” causing a familial form of early onset Alzheimer’s disease, in which she describes how a newly discovered mutation causes early onset familial Alzheimer’s disease. The prize ceremony takes place at the annual meeting of Upsala Läkareförening on September 20.
The Hwasser prize was founded by Upsala Läkareförening to honour the memory of Israel Hwasser, one of Uppsala’s most famous medical scientists. The Hwasser prize foundation is based on a donation to Uppsala University in 1861 by the king Karl XV “to honour Professor Israel Hwasser’s excellent qualities as teacher and scientist”.
This year’s prize sum is 30 000 SEK.
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Theme issue in memory of Björn Smedby
2022-09-06
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The Swedish Social Insurance Agency founds a new research project
2022-08-29
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Covid-19 and work environment in healthcare
2022-08-08
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Anna Mankell receives postdoc funding to study community coproduction
2022-05-30
Anna Mankell, who works in the group for Health and Services Research, has been granted funding from Forte to carry out a postdoc project for two years. Below is a brief summary of the purpose of the study.
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Sexual and gender-based harassment at work can lead to an increased risk of treatment with antidepressants or anti-anxiety drugs.
2022-04-25
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The impact of the pandemic on the work environment
2022-04-25
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New systematic review published regarding work environment and health in organizations during epidemics and pandemics caused by Coronavirus
2022-04-14
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Newly started network on public healthcare management and organization
2022-03-31
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Inger Holmström has been elected to the University Board at Mälardalen University
2022-03-17
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Vinstdriven vård är inte behovsbaserad
2022-03-11
Läs debattartikeln "Vinstdriven vård är inte behovsbaserad" i Läkartidningen.
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Report on central concepts in a knowledge based social service
2022-02-28
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Anna Sarkadi is among those that got a few grants from Forte
2022-02-10
Anna Sarkadi and her research group are among those who have received a few Forte grant just before Christmas 2021.
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The most significant research article of 2020 by Anna Fäldt and colleagues
2022-01-21
Anna Fäldt and colleagues' article on how parents perceive the ComAlong Toddler intervention offered to parents of children with communication difficulties early in the diagnostic process was named the most influential article in 2020 in the Augmentative and Alternative Communication (AAC) Journal.
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Funds from the Uppsala Region for two new research projects
2022-01-18
Elenor Kaminsky and Robert Sarkadi Kristiansson have been granted funding from the Uppsala Region to carry out a research project each. Elenor's project has been awarded 199 000 SEK and Roberts 505,000 SEK.
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Forskargruppen HEAL uppmärksammas
2021-12-22
Forskargruppen Jämlik hälsa och arbetsliv (HEAL) uppmärksammas för deras forskning om arbetsliv och rehabilitering.
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Folkhälsomyndighetens faktablad med CHAPs forskning
2021-12-17
Folkhälsomyndigheten har publicerat två faktablad om upplevda konsekvenser av covid-19-pandemin bland personer med migrationserfarenhet. Flera i forskargruppen CHAP har deltagit i denna studie som rapporterats i faktabladet.
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Publications about nurses views on discrimination, inequity and difficult calls.
2021-12-07
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"Unga transpersoner och icke-binära mår sämre som grupp"
2021-11-08
Region Gotlands hälsostrateg och doktorand på Uppsala universitet Veronica Hermann har tagit reda på hur ungdomar på Gotland mår med hjälp av enkäter och djupintervjuer.
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New funding from Forte to the Research group in Health Services Research
2021-10-08
Four projects from the Research group in Health Services Research have received funding from Forte. In total, the group have been allocated funds of SEK 12.3 million.
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Debatt i SvD om anknytning och treåringens fall Tim
2021-09-27
DEBATT - BARNRÄTT
"Har migrationsmyndigheterna till fullo förstått vidden av de risker som beslutet i fallet med treårige Tim innebär för ett barns hälsa och utveckling? Den frågan ställer forskare och psykologer. " (SvD) -
New report on how the structural change of Swedish health care is coordinated
2021-09-10
Forskningsgruppen i hälso- och sjukvårdsforskning fick i början av 2021 i uppdrag av den statliga utredningen ”Ökade förutsättningar för hållbara investeringsprojekt i framtidens hälso- och sjukvård (S 2019:03)” att studera samordningen av omställningen mot en nära vård samt högspecialiserad vård utifrån hälso- och sjukvårdens behov av investeringar i vårdbyggnader. Nu är rapporten färdigställd och finns som bilaga i SOU 2017:21 ” Riksintressen i hälso- och sjukvården – stärkt statlig styrning för hållbara vårdinfrastrukturer.” Rapporten är skriven av Ulrika Winblad, Anna-Karin Swenning, Anton Modigh, Emanuel Åhlfeldt, Gustaf Hedström & Mio Fredriksson
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Skönlitterär bok för barn 6-9 år, baserad på insikter från Anna Sarkadis forskning
2021-09-06
Skönlitterär bok för barn 6-9, baserad på insikter från Anna Sarkadis forskning om barns och ungas tankar kring coronapandemin. Utgivning i maj 2022, arbetsnamn "Ramona och den dumma coronan". Nu på måndag, ska vår provläsarpanel, bestående av 6-9 år, läsa och ge synpunkter.
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Report on the implementation of a national model in Swedish municipalities
2021-09-03
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New publication from the Research group Health Services Research
2021-08-24
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Inger Holmström is a co-author to a new book about communication in care
2021-08-16